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フォレスト内科リウマチ科クリニック院長の髙橋広行と申します。
私はこれまで、内科医、リウマチ科医として、筑波大学附属病院、国立国際医療研究センター病院などに勤務し、内科全般の診療と、リウマチ・膠原病における専門診療、研究に従事してまいりました。
これまでの経験を活かし、生活習慣病（高血圧・糖尿病・脂質異常症）から急性期疾患に至るまで、幅広く内科全般を診療させていただきます。
リウマチ科外来を開設
また、関節リウマチ、膠原病などにおける最先端の専門診療にも注力するべく、リウマチ科外来を開設しております。大学病院と同等の専門診療を提供できる体制を整えております。
リウマチや膠原病は、同じご病気でも患者様によって症状や病態が大きく異なります。したがって、お一人おひとりにあわせたきめ細やかな診療を行っていくことが必要です。クリニックだからこそオーダーメイドの質の高い専門診療が実践できると考え、当院の開設を決断するにいたりました。
当院は、リウマチ・膠原病にお悩みの方に安心して通院していただけるよう、患者様のお気持ちに寄り添い、お一人おひとりの強い味方であり続けたいと思っております。
困ったときに頼れるかかりつけ医
内科全般、リウマチ・膠原病のいずれにおいても、困ったときにいつでも相談できる身近な存在でありたいと思っております。
これまで大田区、あるいは蒲田・梅屋敷といった地域には、リウマチ・膠原病を専門とした内科のクリニックがほとんどありませんでした。
しかし、これらの病気ではお痛みやお薬の副作用などのお困りごとが突然現れることがあり、「予約がなくても受診できるクリニックが身近にある」ことが大切だと考えております。
当院はご予約がなくてもいつでも受診いただくことが可能ですので、悩まれる前にまずはご来院いただければと思います。
大森の地の、森のような憩いの場（for rest）となれるよう、名称に願いをこめました。
皆様のお気持ちに寄り添い、ほっとしていただけるクリニックを目指してまいります。
当院が、皆様にとって困ったときに頼れるかかりつけ医となれるよう全力を尽くしてまいりますので、ぜひお気軽にご相談ください。
略歴
- 神奈川県横浜市出身、私立栄光学園高校卒業
- 2009年3月筑波大学医学専門学群医学類 卒業
- 2009年4月筑波大学附属病院
- 2011年4月国立国際医療研究センター病院
- 2013年4月筑波大学附属病院 膠原病・リウマチ・アレルギー内科 医員
- 2015年4月筑波大学 医学医療系 膠原病リウマチアレルギー内科学 助教
- 2017年4月筑波大学附属病院 膠原病・リウマチ・アレルギー内科 病院講師
- 2019年4月筑波大学附属病院 膠原病・リウマチ・アレルギー内科 病院講師・外来医長
- 2021年4月国民健康保険 軽井沢病院 内科・リウマチ科 医長
- 2022年4月国立国際医療研究センター病院 膠原病科 医師
- 2023年9月フォレスト内科リウマチ科クリニック 開院
学位・資格・役職
- 博士（医学）
- 日本内科学会 認定内科医・総合内科専門医
- 日本リウマチ学会 評議員・リウマチ専門医・リウマチ指導医
- 東京内科医会 理事
- 東京都難病指定医
受賞歴
- 2015年10月日本免疫学会 Tadamitsu Kishimoto International Travel Award 受賞
- 2018年 2月The 14th International Symposium on Sjögren’s Syndrome Travel Award （米国） 受賞
- 2018年 3月筑波大学大学院人間総合科学研究科医学系専攻 医学奨励賞 受賞
- 2018年 9月日本シェーグレン症候群学会 奨励賞 受賞
- 2019年 9月2019年度GSKジャパン研究助成 採択
研究活動
- 2016年4月日本学術振興会 科研費 若手研究B 研究代表者（〜2018年3月）
- 2018年4月日本学術振興会 科研費 若手研究 研究代表者（〜2020年3月）
- 2020年4月日本学術振興会 科研費 基盤研究C 研究代表者（〜2023年3月）
■ これまでの業績はこちら（外部サイトへ移動します）
所属学会・団体等
- 日本内科学会 会員
- 日本リウマチ学会 評議員
- 日本糖尿病学会 会員
- 日本臨床免疫学会 会員
- 日本シェーグレン病学会 会員
- 日本医師会 会員
- 東京都医師会 会員
- 大森医師会 会員
- 日本臨床内科医会 会員
学術部 アレルギー・リウマチ班 班員 - 東京内科医会 理事
- 国立国際医療センター膠原病科 診療登録医
- Frontiers in Medicine, Editorial Board of Rheumatology, Associate Editor
- 大田区立大森東中学校 内科学校医
院長業績
論文
COVID-19-associated large-vessel vasculitis with elevated anti-angiotensin converting enzyme 2 antibody: three cases and a review of the literature
Setsuko Oyama, Akihiro Matsunaga, Yoichi Teratake, Hiroyuki Takahashi, Hiroyuki Yamashita, Yukihito Ishizaka, Hiroshi Kaneko
Pathogenic role of IFNγ from activated CD4+ T cells in lupus model mice induced by topical treatment with Toll-like receptor agonist imiquimod.
Tanimura R., Kondo Y., Sato R., Nishino R., Nishiyama T., Tanaka S., Shimizu M., Takahashi H., Furuyama K., Ohyama A., Kitada A., Abe S., Asashima H., Miki H., Tsuboi H., Matsumoto I., Sumida T.
Lupus Nephritis Prolongs Improvement of Serositis in Systemic Lupus Erythematosus
Takuya Harada, Hiroyuki Yamashita, Sotaro Nakajima, Toshiaki Kobayashi, Hiroyuki Takahashi, Hiroshi Kaneko
Effect of climatic environment on immunological features of rheumatoid arthritis
Yuya Kondo, Saori Abe, Hirofumi Toko, Tomoya Hirota, Hiroyuki Takahashi, Masaru Shimizu, Hisashi Noma, Hiroto Tsuboi, Isao Matsumoto, Toshiro Inaba, Takayuki Sumida
Abatacept ameliorates both glandular and extraglandular involvements in patients with Sjögren’s syndrome associated with rheumatoid arthritis: Findings from an open-label, multicentre, 1-year, prospective study: The ROSE (Rheumatoid Arthritis with Orencia Trial Toward Sjögren’s Syndrome Endocrinopathy) and ROSE II trials.
Hiroto Tsuboi, Hirofumi Toko, Fumika Honda, Saori Abe, Hiroyuki Takahashi, Mizuki Yagishita, Shinya Hagiwara, Ayako Ohyama, Yuya Kondo, Kazuhisa Nakano, Yoshiya Tanaka, Toshimasa Shimizu, Hideki Nakamura, Atsushi Kawakami, Yuichiro Fujieda, Tatsuya Atsumi, Yasunori Suzuki, Mitsuhiro Kawano, Naoshi Nishina, Yuko Kaneko, Tsutomu Takeuchi, Hitomi Kobayashi, Masami Takei, Michihiro Ogasawara, Naoto Tamura, Yoshinari Takasaki, Kazuhiro Yokota, Yuji Akiyama, Toshihide Mimura, Kosaku Murakami, Tsuneyo Mimori, Shiro Ohshima, Naoto Azuma, Hajime Sano, Susumu Nishiyama, Isao Matsumoto, Takayuki Sumida
Synovitis-acne-pustulosis-hyperostosis-osteitis Syndrome with Bilateral Pleural Effusion
Maho Adachi-Katayama, Yuya Kondo, Shota Okamoto, Ryota Sato, Satoshi Morinaka, Taihei Nishiyama, Mayu Terasaki, Toshihiko Terasaki, Hirofumi Toko, Mizuki Yagishita, Hiroyuki Takahashi, Shinya Hagiwara, Hiroto Tsuboi, Takayuki Sumida, Isao Matsumoto
QTc interval prolongation in patients with systemic lupus erythematosus treated with hydroxychloroquine
Taihei Nishiyama, Yuya Kondo, Hiroto Tsuboi, Hisashi Noma, Daiki Tabuchi, Toshiki Sugita, Shota Okamoto, Toshihiko Terasaki, Masaru Shimizu, Fumika Honda, Ayako Ohyama, Izumi Kurata, Mizuki Yagishita, Saori Abe, Hiroyuki Takahashi, Atsumu Osada, Shinya Hagiwara, Isao Matsumoto, Takayuki Sumida
Clinical features of large vessel vasculitis (LVV): Elderly-onset versus young-onset
Satoshi Morinaka, Hiroto Tsuboi, Shinya Hagiwara, Toshiki Sugita, Daiki Tabuchi, Ryota Sato, Taihei Nishiyama, Shota Okamoto, Toshihiko Terasaki, Mizuki Yagishita, Hiroyuki Takahashi, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Predictive Factors for Pneumomediastinum During Management of Connective Tissue Disease-related Interstitial Lung Disease: A Retrospective Study
Shota Okamoto, Hiroto Tsuboi, Hisashi Noma, Daiki Tabuchi, Toshiki Sugita, Taihei Nishiyama, Toshihiko Terasaki, Masaru Shimizu, Fumika Honda, Mizuki Yagishita, Ayako Ohyama, Izumi Kurata, Saori Abe, Hiroyuki Takahashi, Atsumu Osada, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Pathogenic roles and therapeutic potential of the CCL8–CCR8 axis in a murine model of IgG4-related sialadenitis
Fumika Honda, Hiroto Tsuboi, Yuko Ono, Saori Abe, Hiroyuki Takahashi, Kiyoaki Ito, Kazunori Yamada, Mitsuhiro Kawano, Yuya Kondo, Kenichi Asano, Masato Tanaka, Marie Malissen, Bernard Malissen, Isao Matsumoto, Takayuki Sumida
Humanized NOD/SCID/IL2rγnull mice exhibit functionally augmented human regulatory T cells associated with enzymatic up-regulation of H3K27me3 in comparison with humans
Hiroyuki Takahashi, Hiroto Tsuboi, Saori Abe, Fumika Honda, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Therapeutic Plasma Exchange Improved Pregnancy-associated Thrombotic Microangiopathy but not the Pregnancy Outcome in Patient with Systemic Lupus Erythematosus
Toshihiko Terasaki, Yuya Kondo, Mayumi Takahashi, Takashi Tawara, Akiko Fujita, Hiroya Yagi, Hitomi Kawai, Masayuki Noguchi, Ryota Sato, Mayu Terasaki, Shota Okamoto, Hirofumi Toko, Mizuki Yagishita, Hiroyuki Takahashi, Shinya Hagiwara, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
Clinical features and prognosis of nocardiosis in patients with connective tissue diseases
Mizuki Yagishita, Hiroto Tsuboi, Daiki Tabuchi, Toshiki Sugita, Taihei Nishiyama, Shota Okamoto, Toshihiko Terasaki, Masaru Shimizu, Fumika Honda, Ayako Ohyama, Izumi Kurata, Saori Abe, Hiroyuki Takahashi, Atsumu Osada, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
M3 muscarinic acetylcholine receptor–reactive Th17 cells in primary Sjögren’s syndrome
Saori Abe, Hiroto Tsuboi, Hanae Kudo, Hiromitsu Asashima, Yuko Ono, Fumika Honda, Hiroyuki Takahashi, Mizuki Yagishita, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Aortic Arch Aneurysm in Behçet Disease Successfully Treated with Infliximab
Taihei Nishiyama, Yuya Kondo, Shota Okamoto, Mayu Terasaki, Hirofumi Toko, Mizuki Yagishita, Hiroyuki Takahashi, Masahiro Yokosawa, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
IgG4-related pleural disease with aortitis and submandibular glands involvement successfully treated with corticosteroid: case-based review
Shota Okamoto, Hiroto Tsuboi, Ryota Sato, Mayu Terasaki, Toshihiko Terasaki, Hirofumi Toko, Masaru Shimizu, Fumika Honda, Mizuki Yagishita, Ayako Ohyama, Izumi Kurata, Saori Abe, Hiroyuki Takahashi, Atsumu Osada, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
RORγt antagonist improves Sjögren’s syndrome‐like sialadenitis through downregulation of CD25
Yuko Ono, Hiroto Tsuboi, Masafumi Moriyama, Hiromitsu Asashima, Hanae Kudo, Hiroyuki Takahashi, Fumika Honda, Saori Abe, Yuya Kondo, Satoru Takahashi, Isao Matsumoto, Seiji Nakamura, Takayuki Sumida
Advantage of Magnetic Resonance Imaging in Detecting Tracheal Involvement and Evaluation of the Therapeutic Response in Relapsing Polychondritis With Asthma-Like Symptoms
Ryota Sato, Hiroyuki Takahashi, Mayu Terasaki, Shota Okamoto, Toshihiko Terasaki, Hirofumi Toko, Mizuki Yagishita, Shinya Hagiawara, Yuya Kondo, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
Successful Treatment With Multitarget Therapy of Mycophenolate Mofetil and Tacrolimus for Cyclophosphamide-Resistant Antineutrophil Cytoplasmic Antibody–Associated Pauci-Immune Glomerulonephritis Developed Independently of Systemic Lupus Erythematosus
Mayu Terasaki, Hiroyuki Takahashi, Ryota Sato, Shota Okamoto, Toshihiko Terasaki, Hirofumi Toko, Mizuki Yagishita, Shinya Hagiawara, Yuya Kondo, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
Detection and Clinical Significance of Circulating M3 Muscarinic Acetylcholine Receptor Reactive Th17 Cells in Patients with Primary Sjögren’s Syndrome [abstract]
Saori Abe, Hiroto Tsuboi, Yuko Ono, Fumika Honda, Mizuki Yagishita, Izumi Kurata, Ayako Ohyama, Hiroyuki Takahashi, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
RORγt Antagonist Attenuates Experimental Sialadenitis Like Sjögren’s Syndrome via Inhibition of CD25 Expression on CD4+ T Cells [abstract]
Yuko Ono, Hiroto Tsuboi, Masafumi Moriyama, Hiroyuki Takahashi, Fumika Honda, Saori Abe, Yuya Kondo, Isao Matsumoto, Seiji Nakamura, Takayuki Sumida
Transgenic rice seeds expressing altered peptide ligands against the M3 muscarinic acetylcholine receptor suppress experimental sialadenitis-like Sjögren’s syndrome
Hanae Kudo, Hiroto Tsuboi, Hiromitsu Asashima, Hiroyuki Takahashi, Yuko Ono, Saori Abe, Fumika Honda, Yuya Kondo, Yuhya Wakasa, Fumio Takaiwa, Makoto Takano, Minoru Matsui, Isao Matsumoto, Takayuki Sumida
Contrast Enhanced Computed Tomography Revealed Gallbladder Hemorrhage Due to Active Vasculitis in a Patient With Microscopic Polyangiitis
Fumika Honda, Hiroto Tsuboi, Hirofumi Toko, Toshihiko Terasaki, Mayu Terasaki, Masaru Shimizu, Ayako Ohyama, Mizuki Yagishita, Hiroyuki Takahashi, Masahiro Yokosawa, Hiromitsu Asashima, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Pathogenesis of IgG4-related disease. Comparison with Sjögren’s syndrome
Hiroto Tsuboi, Fumika Honda, Hiroyuki Takahashi, Yuko Ono, Saori Abe, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Upregulation and pathogenic roles of CCL18-CCR8 axis in IgG4-related disease
Hiroto Tsuboi, Mana Iizuka-Koga, Hiromitsu Asashima, Hiroyuki Takahashi, Hanae Kudo, Yuko Ono, Fumika Honda, Akira Iizuka, Seiji Segawa, Saori Abe, Mizuki Yagishita, Masahiro Yokosawa, Yuya Kondo, Masafumi Moriyama, Isao Matsumoto, Seiji Nakamura, Takayuki Sumida
Effect of Biological Disease-modifying Anti-rheumatic Drugs on Airway and Interstitial Lung Disease in Patients with Rheumatoid Arthritis
Izumi Kurata, Hiroto Tsuboi, Mayu Terasaki, Masaru Shimizu, Hirofumi Toko, Fumika Honda, Ayako Ohyama, Mizuki Yagishita, Atsumu Osada, Hiroshi Ebe, Hoshimi Kawaguchi, Hiroyuki Takahashi, Shinya Hagiwara, Hiromitsu Asashima, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Association of anti-cyclic citrullinated peptide antibody with clinical features in patients with psoriatic arthritis
Shinya Hagiwara, Hiroto Tsuboi, Toshihiko Terasaki, Mayu Terasaki, Hirofumi Toko, Masaru Shimizu, Fumika Honda, Mizuki Yagishita, Ayako Ohyama, Hiroyuki Takahashi, Masahiro Yokosawa, Hiromitsu Asashima, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Renal Sarcoidosis With Multiple Organ Involvement
Masaru Shimizu, Hiromitsu Asashima, Mayu Terasaki, Hirofumi Toko, Fumika Honda, Ayako Ohyama, Mizuki Yagishita, Hiroyuki Takahashi, Shinya Hagiwara, Yuya Kondo, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
Clinically Amyopathic Dermatomyositis with Interstitial Pneumonia That Was Successfully Treated with Plasma Exchange
Mizuki Yagishita, Yuya Kondo, Toshihiko Terasaki, Mayu Terasaki, Masaru Shimizu, Fumika Honda, Ayako Oyama, Hiroyuki Takahashi, Masahiro Yokosawa, Hiromitsu Asashima, Shinya Hagiwara, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
Evidence-based clinical practice guideline for adult Still’s disease
Toshihide Mimura, Yuya Kondo, Akihide Ohta, Masahiro Iwamoto, Akiko Ota, Nami Okamoto, Yasushi Kawaguchi, Hajime Kono, Yoshinari Takasaki, Shuji Takei, Norihiro Nishimoto, Manabu Fujimoto, Yu Funakubo Asanuma, Akio Mimori, Naoko Okiyama, Shunta Kaneko, Hiroyuki Takahashi, Masahiro Yokosawa, Takayuki Sumida
RORγt antagonist suppressed spontaneous sialadenitis in RORγt transgenic mice via inhibition of IL-17 production with increase of regulatory T cells [abstract]
Yuko Ono, Hiroto Tsuboi, Masafumi Moriyama, Hiromitsu Asashima, Hanae Kudo, Hiroyuki Takahashi, Yuya Kondo, Isao Matsumoto, Seiji Nakamura, Takayuki Sumida
Analysis of suppressive ability and its mechanisms of rice seeds expressing altered peptide ligands against M3 muscarinic ace- tylcholine receptor (M3R) induced sialadenitis [abstract]
Hanae Kudo, Hiroto Tsuboi, Hiromitsu Asashima, Hiroyuki Takahashi, Yuko Ono, Saori Abe, Yuya Kondo, Yuya Wakasa, Fumio Takaiwa, Isao Matsumoto, Takayuki Sumida
A potential role of NR4A2 overexpression in CD4+ T cells in the pathogenesis of Sjögren’s syndrome [abstract]
Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Hanae Kudo, Yuko Ono, Saori Abe, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Associations between maternal clinical features and fetal outcomes in pregnancies of mothers with connective tissue diseases
Ayako Ohyama, Hiroto Tsuboi, Hisashi Noma, Mayu Terasaki, Masaru Shimizu, Hirofumi Toko, Fumika Honda, Mizuki Yagishita, Hiroyuki Takahashi, Hiromitsu Asashima, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Clinical practice guideline for Sjögren’s syndrome 2017
Takayuki Sumida, Naoto Azuma, Masafumi Moriyama, Hiroyuki Takahashi, Hiromitsu Asashima, Fumika Honda, Saori Abe, Yuko Ono, Tomoya Hirota, Shintaro Hirata, Yoshiya Tanaka, Toshimasa Shimizu, Hideki Nakamura, Atsushi Kawakami, Hajime Sano, Yoko Ogawa, Kazuo Tsubota, Koufuchi Ryo, Ichiro Saito, Akihiko Tanaka, Seiji Nakamura, Etsuko Takamura, Masao Tanaka, Katsuya Suzuki, Tsutomu Takeuchi, Noriyuki Yamakawa, Tsuneyo Mimori, Akiko Ohta, Susumu Nishiyama, Toshio Yoshihara, Yasunori Suzuki, Mitsuhiro Kawano, Minako Tomiita, Hiroto Tsuboi
Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A
Hoshimi Kawaguchi, Hiroto Tsuboi, Mizuki Yagishita, Toshihiko Terasaki, Mayu Terasaki, Masaru Shimizu, Fumika Honda, Ayako Ohyama, Hiroyuki Takahashi, Haruka Miki, Masahiro Yokosawa, Hiromitsu Asashima, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
DNA Microarray Analysis Identifies Nuclear Receptor Subfamily 4 Group a Member 2 (NR4A2) As a Novel Molecule Involved in the Pathogenesis of Sjögren’s Syndrome [abstract]
Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Hanae Kudo, Yuko Ono, Saori Abe, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjögren’s syndrome
Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Tomoya Hirota, Yuya Kondo, Masafumi Moriyama, Isao Matsumoto, Seiji Nakamura, Takayuki Sumida
Diffusion-weighted magnetic resonance imaging of parotid glands before and after abatacept therapy in patients with Sjögren’s syndrome associated with rheumatoid arthritis: Utility to evaluate and predict response to treatment
Hiroyuki Takahashi, Hiroto Tsuboi, Masahiro Yokosawa, Hiromitsu Asashima, Tomoya Hirota, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Functional Analysis of Dendritic Cells Generated from T-iPSCs from CD4+ T Cell Clones of Sjögren’s Syndrome
Mana Iizuka-Koga, Hiromitsu Asashima, Miki Ando, Chen-Yi Lai, Shinji Mochizuki, Mahito Nakanishi, Toshinobu Nishimura, Hiroto Tsuboi, Tomoya Hirota, Hiroyuki Takahashi, Isao Matsumoto, Makoto Otsu, Takayuki Sumida
Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjögren’s syndrome with other sets of criteria in Japanese patients
Hiroto Tsuboi, Shinya Hagiwara, Hiromitsu Asashima, Hiroyuki Takahashi, Tomoya Hirota, Hisashi Noma, Hisanori Umehara, Atsushi Kawakami, Hideki Nakamura, Hajime Sano, Kazuo Tsubota, Yoko Ogawa, Etsuko Takamura, Ichiro Saito, Hiroko Inoue, Seiji Nakamura, Masafumi Moriyama, Tsutomu Takeuchi, Yoshiya Tanaka, Shintaro Hirata, Tsuneyo Mimori, Isao Matsumoto, Takayuki Sumida
Suppression of glucose-6-phosphate-isomerase induced arthritis by oral administration of transgenic rice seeds expressing altered peptide ligands of glucose-6-phosphate-isomerase
Tomoya Hirota, Hiroto Tsuboi, Mana Iizuka-Koga, Hiroyuki Takahashi, Hiromitsu Asashima, Masahiro Yokosawa, Yuya Kondo, Masaru Ohta, Yuhya Wakasa, Isao Matsumoto, Fumio Takaiwa, Takayuki Sumida
Suppression of GPI-induced arthritis by oral administration of transgenic rice seeds expressing altered peptide ligands.
Tomoya Hirota, Hiroto Tsuboi, Hiroyuki Takahashi, Hiromitsu Asashima, Masaru Ohta, Yuhya Wakasa, Isao Matsumoto, Fumio Takaiwa, Takayuki Sumida
RORγt antagonist suppresses M3 muscarinic acetylcholine receptor-induced Sjögren’s syndrome-like sialadenitis
Masahiro Tahara, Hiroto Tsuboi, Seiji Segawa, Hiromitsu Asashima, Mana Iizuka-Koga, Tomoya Hirota, Hiroyuki Takahashi, Yuya Kondo, Minoru Matsui, Isao Matsumoto, Takayuki Sumida
Effectiveness of abatacept for patients with Sjögren’s syndrome associated with rheumatoid arthritis. An open label, multicenter, one-year, prospective study: ROSE (Rheumatoid Arthritis with Orencia Trial toward Sjögren’s syndrome Endocrinopathy) trial
Hiroto Tsuboi, Isao Matsumoto, Shinya Hagiwara, Tomoya Hirota, Hiroyuki Takahashi, Hiroshi Ebe, Masahiro Yokosawa, Mizuki Yagishita, Hidenori Takahashi, Izumi Kurata, Ayako Ohyama, Fumika Honda, Hiromitsu Asashima, Haruka Miki, Naoto Umeda, Yuya Kondo, Shintaro Hirata, Kazuyoshi Saito, Yoshiya Tanaka, Yoshiro Horai, Hideki Nakamura, Atsushi Kawakami, Takayuki Sumida
A case of refractory Kimura disease with a buccal bulky mass successfully treated with low-dose cyclosporine A: Report and review of the literature
Haruka Miki, Hiroto Tsuboi, Shunta Kaneko, Hiroyuki Takahashi, Masahiro Yokosawa, Hiromitsu Asashima, Tomoya Hirota, Shinya Hagiwara, Naoto Umeda, Yuya Kondo, Bungo Nishimura, Masato Sugano, Isao Matsumoto, Takayuki Sumida
Association of anti-Ro/SSA antibody with response to biologics in patients with rheumatoid arthritis
Shinya Hagiwara, Hiroto Tsuboi, Fumika Honda, Hidenori Takahashi, Izumi Kurata, Ayako Ohyama, Mizuki Yagishita, Saori Abe, Yuko Kurashima, Syunta Kaneko, Hoshimi Kawaguchi, Hiroyuki Takahashi, Hiroshi Ebe, Masahiro Yokosawa, Hiromitsu Asashima, Tomoya Hirota, Naoto Umeda, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
DNA Microarray Analysis of Labial Salivary Glands in Patients with Sjögren’s Syndrome: Comparison with IgG4-Related Disease [abstract]
Hiroyuki Takahashi, Hiroto Tsuboi, Mana Iizuka, Hiromitsu Asashima, Tomoya Hirota, Yuya Kondo, Sachiko Furukawa, Masafumi Moriyama, Isao Matsumoto, Toshio Yoshihara, Seiji Nakamura, Yuji Nakai, Keiko Abe, Takayuki Sumida
Magnetic resonance imaging can reveal fascial vasculitis in a patient with microscopic polyangiitis
Hiroyuki Takahashi, Hiroto Tsuboi, Saori Abe, Masahiro Yokosawa, Shinya Hagiwara, Hiromitsu Asashima, Tomoya Hirota, Naoto Umeda, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
Evaluation of changes in magnetic resonance images following 24 and 52 weeks of treatment of rheumatoid arthritis with infliximab, tocilizumab, or abatacept
Tomoya Hirota, Takeshi Suzuki, Hiroshi Ogishima, Shinya Hagiwara, Hiroshi Ebe, Hiroyuki Takahashi, Masahiro Yokosawa, Naoto Umeda, Yuya Kondo, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
A case of relapsing neurosarcoidosis with brain nodules and hydrocephalus successfully treated by corticosteroid and methotrexate: Fig. 1
Izumi Kurata, Hiroto Tsuboi, Hidenori Takahashi, Mizuki Yagishita, Saori Abe, Hiroshi Ebe, Hiroyuki Takahashi, Hiromitsu Asashima, Tomoya Hirota, Shinya Hagiwara, Naoto Umeda, Yuya Kondo, Hiroshi Ogishima, Takeshi Suzuki, Isao Matsumoto, Takayuki Sumida
The Anergy Induction of M3 Muscarinic Acetylcholine Receptor-Reactive CD4+ T Cells Suppresses Experimental Sialadenitis-like Sjögren’s Syndrome
Hiromitsu Asashima, Hiroto Tsuboi, Hiroyuki Takahashi, Tomoya Hirota, Mana Iizuka, Yuya Kondo, Minoru Matsui, Isao Matsumoto, Takayuki Sumida
[18F]fluorodeoxyglucose positron emission tomography/computed tomography can reveal subclinical prostatitis in a patient with IgG4-related disease
Hiroyuki Takahashi, Hiroto Tsuboi, Hiroshi Ogishima, Masahiro Yokosawa, Hidenori Takahashi, Mizuki Yagishita, Saori Abe, Shinya Hagiwara, Hiromitsu Asashima, Tomoya Hirota, Naoto Umeda, Yuya Kondo, Takeshi Suzuki, Isao Matsumoto, Takayuki Sumida
New Therapeutic Strategy for Sjögren’s Syndrome Associated with Rheumatoid Arthritis Targeted on T cells [abstract]
Hiroto Tsuboi, Isao Matsumoto, Shinya Hagiwara, Tomoya Hirota, Hiroyuki Takahashi, Hiroshi Ebe, Masahiro Yokosawa, Mizuki Yagishita, Hidenori Takahashi, Izumi Kurata, Ayako Ohyama, Fumika Honda, Hiromitsu Asashima, Haruka Miki, Naoto Umeda, Yuya Kondo, Shintaro Hirata, Kazuyoshi Saito, Yoshiya Tanaka, Yoshiro Horai, Hideki Nakamura, Atsushi Kawakami, Takayuki Sumida
A Pathological Role of RORct in the Development of Sialadenitis like Sjögren’s Syndrome [abstract]
Mana Iizuka, Hiroto Tsuboi, Hiromitsu Asashima, Tomoya Hirota, Hiroyuki Takahashi, Yuya Kondo, Satoru Takahashi, Isao Matsumoto, Takayuki Sumida
The anergy induction of M3R reactive CD4+ T cells suppresses experimental sialadenitis like Sjögren’s syndrome in vivo [abstract]
Hiromitsu Asashima, Hiroto Tsuboi, Hiroyuki Takahashi, Tomoya Hirota, Mana Iizuka, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
DNA Microarray Analysis of Labial Salivary Glands in Patients with Sjögren’s Syndrome: Comparison with IgG4-Related Disease [abstract]
Hiroyuki Takahashi, Hiroto Tsuboi, Yuji Nakai, Mana Iizuka, Hiromitsu Asashima, Tomoya Hirota, Yuya Kondo, Masafumi Moriyama, Sachiko Furukawa, Isao Matsumoto, Seiji Nakamura, Toshio Yoshihara, Keiko Abe, Takayuki Sumida
Differences in fluorodeoxyglucose positron emission tomography/computed tomography findings between elderly onset rheumatoid arthritis and polymyalgia rheumatica
Hiroyuki Takahashi, Hiroyuki Yamashita, Kazuo Kubota, Yoko Miyata, Momoko Okasaki, Miyako Morooka, Yuko Takahashi, Hiroshi Kaneko, Toshikazu Kano, Akio Mimori
Predictors of the response to treatment in acute lupus hemophagocytic syndrome
Hiroyuki Takahashi, Hiroto Tsuboi, Izumi Kurata, Hidenori Takahashi, Saori Inoue, Hiroshi Ebe, Masahiro Yokosawa, Shinya Hagiwara, Tomoya Hirota, Hiromitsu Asashima, Shunta Kaneko, Hoshimi Kawaguchi, Yuko Kurashima, Haruka Miki, Naoto Umeda, Yuya Kondo, Hiroshi Ogishima, Takeshi Suzuki, Isao Matsumoto, Takayuki Sumida
[Rheumatology: Progress in Diagnosis and Treatments. Topics: IV. Collagen Diseases Except for Rheumatoid Arthritis and Hot Topics; 7. Sjögren’s syndrome].
Hiroto Tsuboi, Hiromitsu Asashima, Hiroyuki Takahashi, Tomoy Hirota, Takayuki Sumida
Usefulness of MR imaging of the parotid glands in patients with secondary Sjögren’s syndrome associated with rheumatoid arthritis
Masahiro Yokosawa, Hiroto Tsuboi, Katsuhiro Nasu, Chihiro Hagiya, Shinya Hagiwara, Tomoya Hirota, Hiroshi Ebe, Hiroyuki Takahashi, Hiromitsu Asashima, Yuya Kondo, Hiroshi Ogishima, Takeshi Suzuki, Manabu Minami, Hiroki Bukawa, Isao Matsumoto, Takayuki Sumida
Efficacy and safety of abatacept for patients with Sjögren’s syndrome associated with rheumatoid arthritis: Rheumatoid Arthritis with Orencia Trial toward Sjögren’s syndrome Endocrinopathy (ROSE) trial—an open-label, one-year, prospective study—Interim analysis of 32 patients for 24 weeks
Hiroto Tsuboi, Isao Matsumoto, Shinya Hagiwara, Tomoya Hirota, Hiroyuki Takahashi, Hiroshi Ebe, Masahiro Yokosawa, Chihiro Hagiya, Hiromitsu Asashima, Chinatsu Takai, Haruka Miki, Naoto Umeda, Yuya Kondo, Hiroshi Ogishima, Takeshi Suzuki, Shintaro Hirata, Kazuyoshi Saito, Yoshiya Tanaka, Yoshiro Horai, Hideki Nakamura, Atsushi Kawakami, Takayuki Sumida
The utility of FDG-PET/CT and other imaging techniques in the evaluation of IgG4-related disease
Hiroyuki Takahashi, Hiroyuki Yamashita, Miyako Morooka, Kazuo Kubota, Yuko Takahashi, Hiroshi Kaneko, Toshikazu Kano, Akio Mimori
Clinical features of patients with IgG4-related disease complicated with perivascular lesions
Hiroshi Ebe, Hiroto Tsuboi, Chihiro Hagiya, Hiroyuki Takahashi, Masahiro Yokosawa, Shinya Hagiwara, Tomoya Hirota, Yuko Kurashima, Chinatsu Takai, Haruka Miki, Hiromitsu Asashima, Naoto Umeda, Yuya Kondo, Hiroshi Ogishima, Takeshi Suzuki, Yusuke Chino, Isao Matsumoto, Takayuki Sumida
Interstitial cystitis associated with primary Sjögren’s syndrome successfully treated with a combination of tacrolimus and corticosteroid: A case report and literature review
Yo Ueda, Hikaru Tomoe, Hiroyuki Takahashi, Yuko Takahashi, Hiroyuki Yamashita, Hiroshi Kaneko, Toshikazu Kano, Akio Mimori
Utility of fluorodeoxyglucose positron emission tomography/computed tomography for early diagnosis and evaluation of disease activity of relapsing polychondritis: a case series and literature review
Hiroyuki Yamashita, Hiroyuki Takahashi, Kazuo Kubota, Yo Ueda, Takashi Ozaki, Hideki Yorifuji, Ei Bannai, Ryogo Minamimoto, Miyako Morooka, Yoko Miyata, Momoko Okasaki, Yuko Takahashi, Hiroshi Kaneko, Toshikazu Kano, Akio Mimori
Pulmonary nocardiosis in patients with connective tissue disease: A report of two cases
Shinya Hagiwara, Hiroto Tsuboi, Chihiro Hagiya, Masahiro Yokosawa, Tomoya Hirota, Hiroshi Ebe, Hiroyuki Takahashi, Hiroshi Ogishima, Hiromitsu Asashima, Yuya Kondo, Naoto Umeda, Takeshi Suzuki, Shigemi Hitomi, Isao Matsumoto, Takayuki Sumida
Cytomegalovirus disease of the upper gastrointestinal tract in patients with rheumatic diseases: a case series and literature review
Takashi Ozaki, Hiroyuki Yamashita, Shunta Kaneko, Hideki Yorifuji, Hiroyuki Takahashi, Yo Ueda, Yuko Takahashi, Hiroshi Kaneko, Toshikazu Kano, Akio Mimori
Diagnosis and treatment of primary Sjögren syndrome-associated peripheral neuropathy: a six-case series
Hiroyuki Yamashita, Toshiki Eri, Yo Ueda, Takashi Ozaki, Hiroyuki Takahashi, Takahiro Tsuno, Yuko Takahashi, Toshikazu Kano, Akio Mimori
A Japanese Case with Nasu-Hakola Disease of DAP12 Gene Mutation Exhibiting Precuneus Hypoperfusion
Kiyotaka Nakamagoe, Ayako Shioya, Tetsuto Yamaguchi, Hiroyuki Takahashi, Reiko Koide, Tatsuya Monzen, Jun-ichi Satoh, Akira Tamaoka
MISC
IgG4関連疾患
髙橋広行
TLRアゴニスト誘導SLEモデルマウスにおけるPD-1の役割
近藤裕也, 谷村玲央菜, 古山琴菜, 清水優, 高橋広行, 坪井洋人, 松本功, 住田孝之
Toll様受容体7アゴニスト誘導SLEモデルマウスにおけるTh10様細胞の病因的意義
谷村玲央菜, 近藤裕也, 古山琴菜, 清水優, 高橋広行, 坪井洋人, 松本功, 住田孝之
TLRアゴニストであるイミキモドで誘導されたlupusモデルマウスにおける病原性T細胞の経時的変化
谷村玲央菜, 近藤裕也, 古山琴菜, 清水優, 高橋広行, 坪井洋人, 松本功, 住田孝之
TLRアゴニストであるイミキモドで誘導されたLupusモデルマウスにおけるprogrammed cell death-1の役割
近藤裕也, 谷村玲央菜, 古山琴菜, 清水優, 高橋広行, 坪井洋人, 松本功, 住田孝之
抗DNA抗体，抗dsDNA抗体，抗ssDNA抗体
髙橋広行, 住田孝之
RORγtトランスジェニックマウスに自然発症する唾液腺炎に対するRORγtアンタゴニストの唾液腺炎抑制効果と作用メカニズムの解析
小野 由湖, 坪井 洋人, 森山 雅文, 浅島 弘充, 工藤 華枝, 高橋 広行, 近藤 裕也, 松本 功, 中村 誠司, 住田 孝之
免疫アレルギー疾患の病態と分子標的療法 シェーグレン症候群に対するT細胞を標的とした新規治療戦略の可能性
坪井 洋人, 松本 功, 萩原 晋也, 高橋 広行, 横澤 将宏, 浅島 弘充, 近藤 裕也, 平田 信太郎, 齋藤 和義, 田中 良哉, 寳來 吉朗, 中村 英樹, 川上 純, 住田 孝之
連載 疾患からみた細胞表面機能分子 第13回「疾患とNR4A2」
髙橋広行, 坪井洋人, 住田孝之
シェーグレン症候群/IgG4関連疾患 日本人一次性シェーグレン症候群患者の診断における2016年アメリカリウマチ学会-ヨーロッパリウマチ学会新分類基準の検証 従来の3つの診断基準・分類基準との比較
坪井 洋人, 萩原 晋也, 浅島 弘充, 高橋 広行, 廣田 智哉, 梅原 久範, 川上 純, 中村 英樹, 佐野 統, 坪田 一男, 小川 葉子, 高村 悦子, 中村 誠司, 森山 雅文, 竹内 勤, 田中 良哉, 平田 信太郎, 三森 経世, 松本 功, 住田 孝之, 厚生労働科学研究費補助金難治性疾患政策研究事業自己免疫疾患に関する調査研究班
膠原病治療Update:BIOLOGICSを中心に 関節リウマチ合併二次性シェーグレン症候群に対するアバタセプトによる新規治療戦略
坪井洋人, 松本功, 萩原晋也, 廣田智哉, 高橋広行, 江辺広志, 横澤将宏, 柳下瑞希, 高橋秀典, 藏田泉, 大山綾子, 本田文香, 浅島弘充, 三木春香, 梅田直人, 近藤裕也, 住田孝之, 平田信太郎, 齋藤和義, 田中良哉, 寳來吉朗, 中村英樹, 川上純
Sjögren症候群
髙橋広行, 坪井洋人, 住田孝之
関節リウマチ合併二次性シェーグレン症候群に対するアバタセプトの有用性
坪井 洋人, 松本 功, 萩原 晋也, 高橋 広行, 柳下 瑞希, 高橋 秀典, 藏田 泉, 廣田 智哉, 江辺 広志, 横澤 将宏, 浅島 弘充, 梅田 直人, 近藤 裕也, 平田 信太郎, 齋藤 和義, 田中 良哉, 寳來 吉朗, 中村 英樹, 川上 純, 住田 孝之
Clinical vignette
Izumi Kurata, Hiroto Tsuboi, Hidenori Takahashi, Mizuki Yagishita, Saori Abe, Hiroshi Ebe, Hiroyuki Takahashi, Hiromitsu Asashima, Tomoya Hirota, Shinya Hagiwara, Naoto Umeda, Yuya Kondo, Hiroshi Ogishima, Takeshi Suzuki, Isao Matsumoto, Takayuki Sumida
シェーグレン症候群 DNAマイクロアレイによるシェーグレン症候群の唾液腺における遺伝子解析
高橋 広行, 坪井 洋人, 飯塚 麻菜, 浅島 弘充, 廣田 智哉, 近藤 裕也, 森山 雅文, 古川 祥子, 松本 功, 吉原 俊雄, 中村 誠司, 住田 孝之
シェーグレン症候群Update シェーグレン症候群に対するT細胞を標的とした新規治療戦略
坪井 洋人, 松本 功, 萩原 晋也, 廣田 智哉, 高橋 広行, 江辺 広志, 横澤 将宏, 平田 信太郎, 寶來 吉朗, 浅島 弘充, 梅田 直人, 近藤 裕也, 荻島 博, 鈴木 豪, 齋藤 和義, 田中 良哉, 中村 英樹, 川上 純, 住田 孝之
膠原病の新規治療 関節リウマチ合併二次性シェーグレン症候群に対するアバタセプトの有効性と安全性
坪井 洋人, 松本 功, 萩原 晋也, 廣田 智哉, 高橋 広行, 江辺 広志, 横澤 将宏, 浅島 弘充, 高井 千夏, 梅田 直人, 近藤 裕也, 荻島 博, 鈴木 豪, 平田 信太郎, 齋藤 和義, 田中 良哉, 寳來 吉朗, 中村 英樹, 川上 純, 住田 孝之
書籍等出版物
リウマチ病学テキスト改訂第3版（日本リウマチ学会生涯教育委員会・日本リウマチ財団教育研修委員会共同編集）
髙橋広行
Common Diseaseの病態生理と薬物治療
髙橋広行, 坪井洋人, 住田孝之
分子細胞免疫学
浅島弘充, 安部沙織, 近藤裕也, 髙橋広行, 坪井洋人, 住田孝之
成人スチル病診療ガイドライン2017年版
厚生労働科学研究費補助金難治性疾患等政策研究事業自己免疫疾患に関する調査研究班編集
シェーグレン症候群診療ガイドライン2017年版
厚生労働科学研究費補助金難治性疾患等政策研究事業自己免疫疾患に関する調査研究班(研究代表者:住田孝之)編集
膠原病徹底考察ガイド-難治症例とその対策-
髙橋広行